# Claim table — Sinclair longevity protocol / metformin / NMN / resveratrol

| Claim | Evidence label | Assessment |
|---|---:|---|
| David Sinclair is a legitimate aging researcher. | Supported | Harvard lists him as a tenured genetics professor known for aging biology work. |
| His personal/family results prove a protocol works. | Not established | Anecdote and biomarkers are not a controlled trial. Genetics, lifestyle, selection and measurement choices matter. |
| Metformin may target aging biology. | Plausible / trial rationale | TAME and geroscience papers give a rationale, but metformin is approved for diabetes, not anti-aging in healthy people. |
| NMN/resveratrol are proven longevity drugs. | Not established | Human evidence mainly concerns biomarkers such as NAD+ or metabolic/inflammatory markers; lifespan/healthspan proof is missing. |
| Low alcohol, regular exercise, healthy diet and body composition are strong foundations. | Supported | These are consistent with mainstream health evidence and are stronger than any single supplement claim. |
| Viewers should copy the stack. | Not medical advice | Prescription drugs and supplements need clinician review, especially with diabetes risk, kidney/liver disease, drug interactions or cancer history. |