[0.00-3.00] Because NAD levels decline as we age,
[3.00-6.04] researchers have spent years asking an important question.
[6.04-8.04] Can we restore those levels?
[8.04-10.40] And in doing so, support the body's natural
[10.40-11.48] longevity pathways.
[11.48-14.56] That's what led to a growing interest in NAD precursors
[14.56-17.44] or NAD boosters like NMN and NR.
[17.44-18.48] When it comes to NMN,
[18.48-21.52] there's been a number of animal studies showing,
[21.52-23.52] for instance, it restores NAD levels,
[23.52-26.20] it enhances insulin sensitivity.
[26.20-29.68] The machine in my eyes showed that it actually was pretty good
[29.68-31.44] at slowing down the effects of aging.
[31.44-33.20] We've been doing these studies for the last few years
[33.20-34.04] in my life.
[34.04-36.40] Now, preliminary, these mice have less frailty.
[36.40-39.48] We've reported that out in the scientific community.
[39.48-42.16] They seem to be younger, having better activity,
[42.16-44.12] better mitochondrial function, they run further.
[44.12-45.20] The lifespan looks promising.
[45.20-47.68] What are we seeing in the human studies for NMN?
[47.68-49.00] Early results, for instance,
[49.00-52.04] from Yoshino et al in 2021,
[52.04-55.48] showed increased insulin's demulated glucose disposal.
[55.48-57.44] You were pretty excited about it, tell me why.
[57.44-58.76] That's one of the first real proofs
[58.76-62.08] that NMN does something in humans the way it works in mice.
[62.08-63.40] So this was a 10 week study.
[63.40-64.32] It's well done.
[64.32-65.96] It's randomized placebo controlled.
[65.96-68.92] It was 250 milligrams, which is a relatively low dose.