# Claim table — spermidine / autophagy / dosage

| Claim | Evidence label | Assessment |
|---|---:|---|
| Spermidine occurs naturally in foods and the body. | Supported | It is a normal polyamine; wheat germ, legumes/soy, mushrooms and aged cheese are common dietary sources. |
| Spermidine promotes autophagy. | Mechanistic support | Strongest in cell/animal/mechanistic work; human clinical autophagy endpoints are still limited. |
| Human trials prove anti-aging/longevity benefits. | Not established | Human RCTs are small/limited; SmartAge missed its primary cognitive endpoint. |
| It can improve cognition. | Mixed / early | A 30-person pilot suggested benefit; a 100-person 12-month trial did not confirm the primary endpoint. |
| Study-like supplement dose. | Context only | Human trials commonly used about 0.9–1.2 mg/day from wheat-germ extract; no official anti-aging dose exists. |
| Food-first approach is reasonable. | Supported practical framing | Diet provides polyamines plus broader nutrition; supplements add standardization but not proven superiority. |