# Source note — spermidine, autophagy and longevity (2026-09-06)

Original Facebook URL: https://www.facebook.com/share/r/1Cx3RcjkdX/?mibextid=wwXIfr  
Resolved URL: https://m.facebook.com/watch/?v=1281420153975404&_rdr  
Uploader: Notable Brands  
Duration: 37.466 seconds

## What it is
Spermidine is a naturally occurring polyamine found in human cells and foods including wheat germ, soy/legumes, mushrooms, aged cheese and fermented soy products.

## What it might do
The real research hook is autophagy/cellular recycling. Cell and animal studies are stronger than human outcome evidence. Human studies include a small 3-month cognitive pilot and a larger 12-month SmartAge trial. The larger trial did not significantly improve its primary memory endpoint; exploratory inflammation/verbal-memory signals need confirmation.

## Where to get it
Food-first sources: wheat germ, soybeans/natto, mushrooms, green peas, lentils/legumes, whole grains and aged cheeses. Supplements are sold online and in supplement stores, commonly as wheat-germ extract or spermidine trihydrochloride. Choose products that state actual mg of spermidine per serving and provide third-party/batch testing.

## Cost and dosage context
Retail supplement prices vary widely; Canadian/US/UK listings commonly land around CAD/US$25–80 per bottle or roughly CAD/US$20–80 per month depending on capsule strength and serving size. Published human cognitive trials used about 0.9–1.2 mg/day from spermidine-rich wheat-germ extract; some commercial products advertise 1–6 mg/day or higher. There is no official anti-aging dose/RDA.

## Safety line
Not medical advice. Pregnant/breastfeeding people, children, people with wheat/gluten allergy or celiac disease, cancer patients/survivors, immunocompromised people, and anyone on complex medications should ask a clinician before supplementing.